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Effect of resistance training on FTO and PPAR-y genes expression in muscle tissue of obese diabetic rats. | ||
| New Approaches in Exercise Physiology | ||
| دوره 4، شماره 7، شهریور 2022، صفحه 214-235 اصل مقاله (627.2 K) | ||
| نوع مقاله: Research Paper | ||
| شناسه دیجیتال (DOI): 10.22054/nass.2023.71785.1123 | ||
| نویسندگان | ||
| Mehdi Kushkestani1؛ Mahsa Moghadassi2؛ mohsen parvani3؛ raheleh baradaran* 4 | ||
| 1Wellness and lifestyle science initiative group, Ph.D. student of kinesiology and health, school of art and science, Rutgers University New Brunswick, New Brunswick, New Jersey, United States | ||
| 2M.Sc Student of Exercise Physiology, Department of Exercise Physiology, Islamic Azad University, Tehran North Branch, Tehran, Iran | ||
| 3Ph.D. student of Sports Sciences, Faculty of Sports Sciences, University of Coimbra, Portugal | ||
| 4Allameh Bohlool Gonabadi Hospital, Gonabad University of Medical Sciences, Gonabad, Iran | ||
| چکیده | ||
| Purpose: It has been well proven that type 2 diabetes is one of the most common non-communicable diseases leading to many complications and mortality every year. The aim of this study was to investigate the effect of resistance training on FTO and PPAR-y gene expression in muscle tissue of obese diabetic rats. Study design: This experimental study was performed on 12 male Wistar rats (10 weeks old and 220±20 g bodyweight). Methods: Animals received 6 weeks high-fat diet and then in order to induce type 2 diabetes an intraperitoneal injection of a single dose of 30 mg/kg freshly prepared streptozotocin (STZ) (Sigma, USA) solved in citrate buffer (pH 4.5) was performed. Diabetic rats were divided into two (Resistance and control) groups randomly. The resistance program included 6 weeks, 5 sessions per week. The muscle expression of FTO and PPAR-γ was measured using the real-time PCR method. Independent t-test and Analysis of covariance (ANCOVA) were applied to compare the means. Results: The muscle mRNA expression of PPAR-γ and body weight significantly increased after 6 weeks of resistance training (p=0.031, p=0.037; respectively) but there was no significant change in the muscle mRNA expression of FTO (p=0.317). Also, blood glucose significantly decreased in the training group compared to the control group (p=0.01). Conclusion: According to the results of this study, it can be noted that 6-week resistance training by decreasing glucose levels and increases insulin sensitivity, and the muscle expression of PPAR-γ plays a prominent role in the control and treatment of type 2 diabetes in obese patients. | ||
| کلیدواژهها | ||
| Exercise؛ Metabolic diseases؛ Gene expression؛ Diabetics؛ Resistance training | ||
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