| تعداد نشریات | 63 |
| تعداد شمارهها | 2,275 |
| تعداد مقالات | 18,768 |
| تعداد مشاهده مقاله | 58,821,236 |
| تعداد دریافت فایل اصل مقاله | 30,191,194 |
The effect of endurance training on serum glucose levels, weight changes and IGF-1 protein expression in the hippocampus of diabetic rats. | ||
| New Approaches in Exercise Physiology | ||
| مقاله 11، دوره 5، شماره 9، شهریور 2023، صفحه 161-179 اصل مقاله (888.12 K) | ||
| نوع مقاله: Research Paper | ||
| شناسه دیجیتال (DOI): 10.22054/nass.2024.77817.1151 | ||
| نویسندگان | ||
| Naser Behpoor1؛ Saeid Naeimi2؛ Ahmad Fasihi* 3 | ||
| 1Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Razi University, Kermanshah, Iran. | ||
| 2Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Boroujerd Branch, Islamic Azad University, Boroujerd, Iran. | ||
| 3Mohaghegh Ardabili Univercity | ||
| چکیده | ||
| Purpose: Diabetes mellitus is the most common metabolic problem worldwide, which is associated with hyperglycemia and structural and functional disorders of the nervous system. The aim of the present study was to investigate the effect of endurance training on serum glucose levels, weight changes and Like Growth Factor 1 (IGF-1) protein expression in the hippocampus of diabetic rats. Method: For this study, the samples included 48 male Wistar rats (8 weeks old), which were divided into 4 groups: control (C), the diabetes control (DC), diabetes-training (DT) and exercise (T). In order to induce diabetes, streptozotocin injection was used. 5 sessions per week of endurance activity were performed for 6 weeks. 48 hours after the completion of the exercise program, hippocampal tissue was dissected and extracted. ELISA method and one-way variance test were used to analyze the data. Resalts: Based on the results, serum glucose levels decreased after six weeks of endurance training (p=0.001). The amount of IGF-1 in group DC was significantly lower compared to all groups DT, T, and C (P≤0.05). But the DT group had no significant difference with the C and T groups (P=0.210 and P=0.226, respectively). On the other hand, the amount of IGF-1 in group T was only significantly different from group D (P=0.001). The correlation between blood glucose and IGF-1 was significant (p=0.001, r=0.820). Conclusion: Diabetes reduces IGF-1 and hyperglycemia, but exercise moderates the effect of diabetes on IGF-1. Considering the appropriate duration of training and the correlation of this protein with blood glucose, maybe endurance training can reduce the negative effect of diabetes. | ||
| کلیدواژهها | ||
| Diabetes؛ Endurance Training؛ Hippocampus؛ IGF-1 | ||
| مراجع | ||
|
Abdul Basith Khan, M., Hashim, M. J., King, J. K., Govender, R. D., Mustafa, H., & Al Kaabi, J. (2020). Epidemiology of type 2 diabetes—global burden of disease and forecasted trends. Journal of epidemiology and global health, 10(1), 107-111.
Al-Samerria, S., & Radovick, S. (2021). The role of insulin-like growth factor-1 (IGF-1) in the control of neuroendocrine regulation of growth. Cells, 10(10), 2664.
Alizadeh, A. A., Rahmani-Nia, F., Mohebbi, H., & Zakerkish, M. (2016). Acute aerobic exercise and plasma levels of orexin a, insulin, glucose, and insulin resistance in males with type 2 diabetes. Jundishapur Journal of Health Sciences, 8(1).
Awuchi, C. G., Echeta, C. K., & Igwe, V. S. (2020). Diabetes and the nutrition and diets for its prevention and treatment: A systematic review and dietetic perspective. Health Sciences Research, 6(1), 5-19.
Barcelos, R. P., Lima, F. D., Carvalho, N. R., Bresciani, G., & Royes, L. F. (2020). Caffeine effects on systemic metabolism, oxidativeinflammatory pathways, and exercise performance. Nutrition Research, 80, 1-17.
Barone, E., Di Domenico, F., Perluigi, M., & Butterfield, D. A. (2021). The interplay among oxidative stress, brain insulin resistance and AMPK dysfunction contribute to neurodegeneration in type 2 diabetes and Alzheimer disease. Free Radical Biology and Medicine, 176, 16-33.
Bertram, S., Brixius, K., & Brinkmann, C. (2016). Exercise for the diabetic brain: how physical training may help prevent dementia and
Alzheimer’s disease in T2DM patients. Endocrine, 53, 350-363.
Borges, M. E., Ribeiro, A. M., Pauli, J. R., Arantes, L. M., Luciano, E., de Moura, L. P., . . . Sibuya, C. Y. (2017). Cerebellar Insulin/IGF-1 signaling in diabetic rats: Effects of exercise training. Neuroscience letters, 639, 157-161.
Candeias, E., Sebastião, I., Cardoso, S., Carvalho, C., Santos, M. S., Oliveira, C. R., . . . Duarte, A. I. (2018). Brain GLP-1/IGF-1 signaling and autophagy mediate exendin-4 protection against apoptosis in type 2 diabetic rats. Molecular neurobiology, 55, 4030-4050.
Colberg, S. R., Sigal, R. J., Fernhall, B., Regensteiner, J. G., Blissmer, B. J., Rubin, R. R., . . . Braun, B. (2010). Exercise and type 2 diabetes: the
American College of Sports Medicine and the American Diabetes Association: joint position statement. Diabetes care, 33(12), e147e167.
Colberg, S. R., Sigal, R. J., Yardley, J. E., Riddell, M. C., Dunstan, D. W., Dempsey, P. C., . . . Tate, D. F. (2016). Physical activity/exercise and diabetes: a position statement of the American Diabetes Association. Diabetes care, 39(11), 2065.
Daneshyar, S., Gharakhanlou, R., Nikooie, R., & Forutan, Y. (2014). The effect of high-fat diet and streptozotocin-induced diabetes and endurance training on plasma levels of calcitonin gene-related peptide and lactate in rats. Canadian Journal of Diabetes, 38(6), 461-465.
Daryabor, G., Atashzar, M. R., Kabelitz, D., Meri, S., & Kalantar, K. (2020). The effects of type 2 diabetes mellitus on organ metabolism and the immune system. Frontiers in Immunology, 11, 1582.
Demir, S., Nawroth, P. P., Herzig, S., & Ekim Üstünel, B. (2021). Emerging targets in type 2 diabetes and diabetic complications. Advanced Science, 8(18), 2100275.
Duran, R., PANCUR, S., & Bahadori, F. (2022). The Effect of Type 2
Diabetes Mellitus on the Development of Alzheimer’s Disease and Its Molecular Mechanism. Bezmialem Science, 10(1).
El Assar, M., Álvarez-Bustos, A., Sosa, P., Angulo, J., & Rodríguez-Mañas, L. (2022). Effect of physical activity/exercise on oxidative stress and inflammation in muscle and vascular aging. International Journal of Molecular Sciences, 23(15), 8713.
Frier, B. C. (2009). The Influence of Exercise on Inflammation and IGF-1
Signaling in Diabetes. School of Graduate and Postdoctoral Studies, University of Western Ontario,
Gillett, M., Royle, P., Snaith, A., Scotland, G., Poobalan, A., Imamura, M., . . . Wyness, L. (2012). Non-pharmacological interventions to reduce the risk of diabetes in people with impaired glucose regulation: a systematic review and economic evaluation. Health technology assessment, 16(33).
Liu, Y., Yan, T., Chu, J. M.-T., Chen, Y., Dunnett, S., Ho, Y.-S., . . . Chang, R. C.-C. (2019). The beneficial effects of physical exercise in the brain and related pathophysiological mechanisms in neurodegenerative diseases. Laboratory Investigation, 99(7), 943-957. M Ashraf, G., H Greig, N., A Khan, T., Hassan, I., Tabrez, S., Shakil, S., . . . R Jabir, N. (2014). Protein misfolding and aggregation in Alzheimer’s disease and type 2 diabetes mellitus. CNS & Neurological DisordersDrug Targets (Formerly Current Drug Targets-CNS & Neurological Disorders), 13(7), 1280-1293.
Min, H., Zhu, S., Safi, L., Alkourdi, M., Nguyen, B. H., Upadhyay, A., & Tran, S. D. (2023). Salivary Diagnostics in Pediatrics and the Status of Saliva-Based Biosensors. Biosensors, 13(2), 206.
Moham, S. (2010). The Effects of Obesity on the Relationships Among
Insulin-like Growth Factor 1 and Markers of Diabetes. Bowling Green State University,
Mohammadi, E., Fathi, M., Chehel Cheraghi, F., & Nazari, A. (2023). Effect of a Six-week Endurance Exercise Program and Empagliflozin Consumption on Some Structural and Functional Indices of the Heart in Male Diabetic Rats. Iranian Journal of Diabetes and Metabolism.
Mukhtar, Y., Galalain, A., & Yunusa, U. (2020). A modern overview on diabetes mellitus: a chronic endocrine disorder. European Journal of Biology, 5(2), 1-14.
Ortiz, G. G., Huerta, M., González-Usigli, H. A., Torres-Sánchez, E. D., Delgado-Lara, D. L., Pacheco-Moisés, F. P., . . . Velázquez-Brizuela, I. E. (2022). Cognitive disorder and dementia in type 2 diabetes mellitus. World Journal of Diabetes, 13(4), 319.
Pedersen, B. K. (2019). Physical activity and muscle–brain crosstalk. Nature Reviews Endocrinology, 15(7), 383-392.
Rosen, C. J., & Yakar, S. (2020). Growth hormone, insulin-like growth factors, and IGF binding proteins. Principles of bone biology, 9851015.
Sigal, R. J., Kenny, G. P., Wasserman, D. H., Castaneda-Sceppa, C., & White, R. D. (2006). Physical activity/exercise and type 2 diabetes: a consensus statement from the American Diabetes Association. Diabetes care, 29(6), 1433-1438.
Slattery, K., Bentley, D., & Coutts, A. J. (2015). The role of oxidative, inflammatory and neuroendocrinological systems during exercise stress in athletes: implications of antioxidant supplementation on physiological adaptation during intensified physical training. Sports Medicine, 45, 453-471.
Sonntag, W. E., Ramsey, M., & Carter, C. S. (2005). Growth hormone and insulin-like growth factor-1 (IGF-1) and their influence on cognitive aging. Ageing research reviews, 4(2), 195-212.
Tomić, L. (2020). Diabetes as a risk factor for neurodegenerative diseases. University of Zagreb. School of Medicine. Department of Pharmacology,
Vardatsikos, G., Sahu, A., & Srivastava, A. K. (2009). The insulin-like growth factor family: molecular mechanisms, redox regulation, and clinical implications. Antioxidants & redox signaling, 11(5), 11651190.
Wu, Y., Ding, Y., Tanaka, Y., & Zhang, W. (2014). Risk factors contributing to type 2 diabetes and recent advances in the treatment and prevention. International journal of medical sciences, 11(11), 1185.
Zalouli, V., Rajavand, H., Bayat, M., Khaleghnia, J., Sharifianjazi, F., Jafarinazhad, F., & Beheshtizadeh, N. (2023). Adult hippocampal neurogenesis (AHN) controls central nervous system and promotes peripheral nervous system regeneration via physical exercise. Biomedicine & Pharmacotherapy, 165, 115078.
Zanuso, S., Sacchetti, M., Sundberg, C. J., Orlando, G., Benvenuti, P., & Balducci, S. (2017). Exercise in type 2 diabetes: genetic, metabolic and neuromuscular adaptations. A review of the evidence. British journal of sports medicine.
Zemva, J., & Schubert, M. (2014). The role of neuronal insulin/insulin-like growth factor-1 signaling for the pathogenesis of Alzheimer’s disease: possible therapeutic implications. CNS & Neurological DisordersDrug Targets (Formerly Current Drug Targets-CNS & Neurological Disorders), 13(2), 322-337.
Zhou, G., Yan, M., Guo, G., & Tong, N. (2019). Ameliorative effect of berberine on neonatally induced type 2 diabetic neuropathy via modulation of BDNF, IGF-1, PPAR-γ, and AMPK expressions. DoseResponse, 17(3), 1559325819862449. | ||
|
آمار تعداد مشاهده مقاله: 247 تعداد دریافت فایل اصل مقاله: 355 |
||