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Exercise Reversing Aging Process and Inducing Longevity by FOXO Proteins Family | ||
| New Approaches in Exercise Physiology | ||
| دوره 6، شماره 11، شهریور 2024 | ||
| نوع مقاله: Review Article | ||
| شناسه دیجیتال (DOI): 10.22054/nass.2025.85287.1174 | ||
| نویسندگان | ||
| Ashrafsadat Anvarimanshadi* 1؛ Behzad Hajizadeh Maleki2؛ nasrin rafizadeh3؛ Davood Sabour3؛ Elnaz Safikhani3؛ Amirhossein Jafari3 | ||
| 1Faculty of Physical Education and Sport Sciences, Exercise Physiology, Allameh Tabataba’i University | ||
| 2Department of Exercise Physiology and Sports Therapy, Kugelberg 62, Justus-Liebig-University, Giessen, Germany | ||
| 3Faculty of Physical Education and Sports Sciences, Allameh Tabataba’i University, Tehran, Iran | ||
| چکیده | ||
| Aging is influenced by a wide range of biological processes, with increasing attention focused on physical exercise as an effective, non-pharmacological intervention to support healthy aging and extend lifespan. This review examines how exercise influences aging mechanisms by activating Forkhead Box O (FOXO) proteins—especially FOXO3, a critical regulator of oxidative stress resistance, metabolism, and cellular repair. By integrating evidence from both animal models and human studies, we explore how different types of physical activity, including endurance and resistance training, enhance FOXO signaling pathways that govern mitochondrial health, autophagy, and inflammation control. FOXO activation appears to play a central role in mitigating age-related diseases such as sarcopenia, cardiovascular disease, neurodegeneration, and cancer. While preclinical studies consistently demonstrate these protective effects, human data are more variable, highlighting the influence of age, sex, and intervention type. Understanding the molecular connection between exercise and FOXO activity can help develop targeted exercise recommendations to promote longevity and delay age-associated functional decline. | ||
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