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Ghorbani Asiabar, Mojtaba, Ghorbani Asiabar, Morteza, Ghorbani Asiabar, Alireza. (1403). The Role of Genetic and Metabolomic Profiling in Response to High-Intensity Interval Training (HIIT) Among Individuals with Moderate Fitness Levels. سامانه مدیریت نشریات علمی, 6(11), -. doi: 10.22054/nass.2025.86341.1175
Mojtaba Ghorbani Asiabar; Morteza Ghorbani Asiabar; Alireza Ghorbani Asiabar. "The Role of Genetic and Metabolomic Profiling in Response to High-Intensity Interval Training (HIIT) Among Individuals with Moderate Fitness Levels". سامانه مدیریت نشریات علمی, 6, 11, 1403, -. doi: 10.22054/nass.2025.86341.1175
Ghorbani Asiabar, Mojtaba, Ghorbani Asiabar, Morteza, Ghorbani Asiabar, Alireza. (1403). 'The Role of Genetic and Metabolomic Profiling in Response to High-Intensity Interval Training (HIIT) Among Individuals with Moderate Fitness Levels', سامانه مدیریت نشریات علمی, 6(11), pp. -. doi: 10.22054/nass.2025.86341.1175
Ghorbani Asiabar, Mojtaba, Ghorbani Asiabar, Morteza, Ghorbani Asiabar, Alireza. The Role of Genetic and Metabolomic Profiling in Response to High-Intensity Interval Training (HIIT) Among Individuals with Moderate Fitness Levels. سامانه مدیریت نشریات علمی, 1403; 6(11): -. doi: 10.22054/nass.2025.86341.1175

The Role of Genetic and Metabolomic Profiling in Response to High-Intensity Interval Training (HIIT) Among Individuals with Moderate Fitness Levels

New Approaches in Exercise Physiology
دوره 6، شماره 11، شهریور 2024
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22054/nass.2025.86341.1175
نویسندگان
Mojtaba Ghorbani Asiabar* 1؛ Morteza Ghorbani Asiabar2؛ Alireza Ghorbani Asiabar2
1Post-doctorate in Physical Education, Farhangian University, Qazvin, Iran.
2Payam Noor University, Qazvin, Iran
چکیده
Purpose:This study aimed to investigate the influence of genetic polymorphisms and metabolomic profiles on physiological adaptations to a 6-week High-Intensity Interval Training (HIIT) program in individuals with moderate fitness levels, addressing the variability in exercise response.Methodology:Thirty moderately fit adults participated in a supervised 6-week HIIT intervention. Pre- and post-training assessments included VO2max, lactate threshold, genetic profiling of key polymorphisms (e.g., PPARGC1A rs8192678) using PCR and next-generation sequencing, and untargeted metabolomic analysis via liquid chromatography-mass spectrometry (LC-MS). Statistical analyses involved paired t-tests, multivariate regression, principal component analysis (PCA), and partial least squares discriminant analysis (PLS-DA).Results:Significant improvements were observed in VO2max (p < 0.001) and lactate threshold (p = 0.004). Carriers of the PPARGC1A G allele showed greater aerobic capacity gains, accompanied by upregulation of PGC-1α expression. Metabolomic profiling revealed significant shifts in glucose and lipid metabolism pathways post-HIIT. Multivariate models identified interactions between genetic variants and metabolomic changes that predicted individual training responsiveness.Conclusion:Integrating genetic and metabolomic data enhances understanding of individual variability in HIIT adaptations and supports the development of personalized exercise prescriptions to optimize health and performance outcomes.
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تعداد مشاهده مقاله: 72


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