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The Role of Genetic and Metabolomic Profiling in Response to High-Intensity Interval Training (HIIT) Among Individuals with Moderate Fitness Levels | ||
| New Approaches in Exercise Physiology | ||
| دوره 6، شماره 11، شهریور 2024، صفحه 181-204 اصل مقاله (475.29 K) | ||
| نوع مقاله: Research Paper | ||
| شناسه دیجیتال (DOI): 10.22054/nass.2025.86341.1175 | ||
| نویسندگان | ||
| Mojtaba Ghorbani Asiabar* 1؛ Morteza Ghorbani Asiabar2؛ Alireza Ghorbani Asiabar2 | ||
| 1Post-doctorate in Physical Education, Farhangian University, Qazvin, Iran. | ||
| 2Payam Noor University, Qazvin, Iran | ||
| چکیده | ||
| Purpose: This study aimed to investigate the influence of genetic polymorphisms and metabolomic profiles on physiological adaptations to a 6-week High-Intensity Interval Training (HIIT) program in individuals with moderate fitness levels, addressing the variability in exercise response. Method: Thirty moderately fit adults participated in a supervised 6-week HIIT intervention. Pre- and post-training assessments included VO2max, lactate threshold, genetic profiling of key polymorphisms (e.g., PPARGC1A rs8192678) using PCR and next-generation sequencing, and untargeted metabolomic analysis via liquid chromatography-mass spectrometry (LC-MS). Statistical analyses involved paired t-tests, multivariate regression, principal component analysis (PCA), and partial least squares discriminant analysis (PLS-DA). Results: Significant improvements were observed in VO2max (p < 0.001) and lactate threshold (p = 0.004). Carriers of the PPARGC1A G allele showed greater aerobic capacity gains, accompanied by upregulation of PGC-1α expression. Metabolomic profiling revealed significant shifts in glucose and lipid metabolism pathways post-HIIT. Multivariate models identified interactions between genetic variants and metabolomic changes that predicted individual training responsiveness. Conclusion: Integrating genetic and metabolomic data enhances understanding of individual variability in HIIT adaptations and supports the development of personalized exercise prescriptions to optimize health and performance outcomes. | ||
| کلیدواژهها | ||
| Mitochondrial Biogenesis؛ Personalized Exercise؛ Aerobic Capacity؛ Genetic Polymorphism؛ Metabolic Adaptation | ||
| مراجع | ||
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