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Ghorbani Asiabar, Mojtaba, Ghorbani Asiabar, Morteza, Ghorbani Asiabar, Alireza. (1403). The Role of Genetic and Metabolomic Profiling in Response to High-Intensity Interval Training (HIIT) Among Individuals with Moderate Fitness Levels. سامانه مدیریت نشریات علمی, 6(11), 181-204. doi: 10.22054/nass.2025.86341.1175
Mojtaba Ghorbani Asiabar; Morteza Ghorbani Asiabar; Alireza Ghorbani Asiabar. "The Role of Genetic and Metabolomic Profiling in Response to High-Intensity Interval Training (HIIT) Among Individuals with Moderate Fitness Levels". سامانه مدیریت نشریات علمی, 6, 11, 1403, 181-204. doi: 10.22054/nass.2025.86341.1175
Ghorbani Asiabar, Mojtaba, Ghorbani Asiabar, Morteza, Ghorbani Asiabar, Alireza. (1403). 'The Role of Genetic and Metabolomic Profiling in Response to High-Intensity Interval Training (HIIT) Among Individuals with Moderate Fitness Levels', سامانه مدیریت نشریات علمی, 6(11), pp. 181-204. doi: 10.22054/nass.2025.86341.1175
Ghorbani Asiabar, Mojtaba, Ghorbani Asiabar, Morteza, Ghorbani Asiabar, Alireza. The Role of Genetic and Metabolomic Profiling in Response to High-Intensity Interval Training (HIIT) Among Individuals with Moderate Fitness Levels. سامانه مدیریت نشریات علمی, 1403; 6(11): 181-204. doi: 10.22054/nass.2025.86341.1175

The Role of Genetic and Metabolomic Profiling in Response to High-Intensity Interval Training (HIIT) Among Individuals with Moderate Fitness Levels

New Approaches in Exercise Physiology
دوره 6، شماره 11، شهریور 2024، صفحه 181-204    اصل مقاله (475.29 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22054/nass.2025.86341.1175
نویسندگان
Mojtaba Ghorbani Asiabar* 1؛ Morteza Ghorbani Asiabar2؛ Alireza Ghorbani Asiabar2
1Post-doctorate in Physical Education, Farhangian University, Qazvin, Iran.
2Payam Noor University, Qazvin, Iran
چکیده
Purpose: This study aimed to investigate the influence of genetic polymorphisms and metabolomic profiles on physiological adaptations to a 6-week High-Intensity Interval Training (HIIT) program in individuals with moderate fitness levels, addressing the variability in exercise response. Method: Thirty moderately fit adults participated in a supervised 6-week HIIT intervention. Pre- and post-training assessments included VO2max, lactate threshold, genetic profiling of key polymorphisms (e.g., PPARGC1A rs8192678) using PCR and next-generation sequencing, and untargeted metabolomic analysis via liquid chromatography-mass spectrometry (LC-MS). Statistical analyses involved paired t-tests, multivariate regression, principal component analysis (PCA), and partial least squares discriminant analysis (PLS-DA). Results: Significant improvements were observed in VO2max (p < 0.001) and lactate threshold (p = 0.004). Carriers of the PPARGC1A G allele showed greater aerobic capacity gains, accompanied by upregulation of PGC-1α expression. Metabolomic profiling revealed significant shifts in glucose and lipid metabolism pathways post-HIIT. Multivariate models identified interactions between genetic variants and metabolomic changes that predicted individual training responsiveness. Conclusion: Integrating genetic and metabolomic data enhances understanding of individual variability in HIIT adaptations and supports the development of personalized exercise prescriptions to optimize health and performance outcomes.
کلیدواژه‌ها
Mitochondrial Biogenesis؛ Personalized Exercise؛ Aerobic Capacity؛ Genetic Polymorphism؛ Metabolic Adaptation
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تعداد مشاهده مقاله: 2,405
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