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The effect of endurance training on weight changes, serum glucose levels, and NLRP-1 protein expression in the hippocampus of male rats with diabetes | ||
| New Approaches in Exercise Physiology | ||
| دوره 7، شماره 13، شهریور 2025 | ||
| نوع مقاله: Research Paper | ||
| شناسه دیجیتال (DOI): 10.22054/nass.2025.89873.1195 | ||
| نویسندگان | ||
| Mohammad Ahadiyan* 1؛ Mohammad karimjuzani2 | ||
| 1Department of Exercise Physiology, Faculty of Physical Education, Pardis Shomal University, Amol, Iran | ||
| 2Department of Exercise Physiology, Faculty of Humanities, Islamic Azad University, Hamedan Branch, Hamedan, Iran | ||
| چکیده | ||
| Objective; Type 2 diabetes is a chronic metabolic disorder that, in addition to causing metabolic disturbances, has detrimental effects on the central nervous system, particularly the hippocampus. Methods: In this experimental study, 28 male Wistar rats, aged 10 weeks and weighing 245 grams, were divided into four groups: diabetic control, diabetic exercise, healthy control, and healthy exercise. Diabetes was induced by intraperitoneal injection of streptozotocin (STZ). Results :The results showed that endurance training significantly reduced serum glucose levels and stabilized body weight in the diabetic exercise group compared to the diabetic control group (p<0.05). Discussion: These findings indicate that endurance training positively impacts glucose metabolism and reduces neuroinflammation in a diabetic rat model. The decrease in NLRP-1 expression in the hippocampus suggests that endurance exercise has anti-inflammatory and neuroprotective effects. Conclusion: Endurance training, as a non-pharmacological strategy, could improve the management of diabetes and prevent neural damage in diabetic individuals. | ||
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