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Ahadiyan, Mohammad, karimjuzani, Mohammad. (1404). The effect of endurance training on weight changes, serum glucose levels, and NLRP-1 protein expression in the hippocampus of male rats with diabetes. سامانه مدیریت نشریات علمی, 7(13), -. doi: 10.22054/nass.2025.89873.1195
Mohammad Ahadiyan; Mohammad karimjuzani. "The effect of endurance training on weight changes, serum glucose levels, and NLRP-1 protein expression in the hippocampus of male rats with diabetes". سامانه مدیریت نشریات علمی, 7, 13, 1404, -. doi: 10.22054/nass.2025.89873.1195
Ahadiyan, Mohammad, karimjuzani, Mohammad. (1404). 'The effect of endurance training on weight changes, serum glucose levels, and NLRP-1 protein expression in the hippocampus of male rats with diabetes', سامانه مدیریت نشریات علمی, 7(13), pp. -. doi: 10.22054/nass.2025.89873.1195
Ahadiyan, Mohammad, karimjuzani, Mohammad. The effect of endurance training on weight changes, serum glucose levels, and NLRP-1 protein expression in the hippocampus of male rats with diabetes. سامانه مدیریت نشریات علمی, 1404; 7(13): -. doi: 10.22054/nass.2025.89873.1195

The effect of endurance training on weight changes, serum glucose levels, and NLRP-1 protein expression in the hippocampus of male rats with diabetes

New Approaches in Exercise Physiology
دوره 7، شماره 13، شهریور 2025
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22054/nass.2025.89873.1195
نویسندگان
Mohammad Ahadiyan* 1؛ Mohammad karimjuzani2
1Department of Exercise Physiology, Faculty of Physical Education, Pardis Shomal University, Amol, Iran
2Department of Exercise Physiology, Faculty of Humanities, Islamic Azad University, Hamedan Branch, Hamedan, Iran
چکیده
Objective; Type 2 diabetes is a chronic metabolic disorder that, in addition to causing metabolic disturbances, has detrimental effects on the central nervous system, particularly the hippocampus. Methods: In this experimental study, 28 male Wistar rats, aged 10 weeks and weighing 245 grams, were divided into four groups: diabetic control, diabetic exercise, healthy control, and healthy exercise. Diabetes was induced by intraperitoneal injection of streptozotocin (STZ). Results :The results showed that endurance training significantly reduced serum glucose levels and stabilized body weight in the diabetic exercise group compared to the diabetic control group (p<0.05). Discussion: These findings indicate that endurance training positively impacts glucose metabolism and reduces neuroinflammation in a diabetic rat model. The decrease in NLRP-1 expression in the hippocampus suggests that endurance exercise has anti-inflammatory and neuroprotective effects. Conclusion: Endurance training, as a non-pharmacological strategy, could improve the management of diabetes and prevent neural damage in diabetic individuals.
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تعداد مشاهده مقاله: 26


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