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Sayevand, Zahra, Maleki, Marziyeh, Khosravi, Mahdiyeh. (1405). Changes in serum levels of interleukin 4 and malondialdehyde (MDA) following 8 weeks of aquatic aerobic training in breast cancer survivors. سامانه مدیریت نشریات علمی, 8(15), -. doi: 10.22054/nass.2025.90179.1218
Zahra Sayevand; Marziyeh Maleki; Mahdiyeh Khosravi. "Changes in serum levels of interleukin 4 and malondialdehyde (MDA) following 8 weeks of aquatic aerobic training in breast cancer survivors". سامانه مدیریت نشریات علمی, 8, 15, 1405, -. doi: 10.22054/nass.2025.90179.1218
Sayevand, Zahra, Maleki, Marziyeh, Khosravi, Mahdiyeh. (1405). 'Changes in serum levels of interleukin 4 and malondialdehyde (MDA) following 8 weeks of aquatic aerobic training in breast cancer survivors', سامانه مدیریت نشریات علمی, 8(15), pp. -. doi: 10.22054/nass.2025.90179.1218
Sayevand, Zahra, Maleki, Marziyeh, Khosravi, Mahdiyeh. Changes in serum levels of interleukin 4 and malondialdehyde (MDA) following 8 weeks of aquatic aerobic training in breast cancer survivors. سامانه مدیریت نشریات علمی, 1405; 8(15): -. doi: 10.22054/nass.2025.90179.1218

Changes in serum levels of interleukin 4 and malondialdehyde (MDA) following 8 weeks of aquatic aerobic training in breast cancer survivors

New Approaches in Exercise Physiology
دوره 8، شماره 15، شهریور 2026
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22054/nass.2025.90179.1218
نویسندگان
Zahra Sayevand* 1؛ Marziyeh Maleki2؛ Mahdiyeh Khosravi3
1Department of Physical Education, Mal.C., Islamic Azad University, Malayer Branch, Malayer, Iran
2Malayer
3kermanshah
چکیده
Objective: Breast cancer is one of the most common cancers affecting women worldwide, with survivors often experiencing long-term side effects such as chronic inflammation and oxidative stress. The objective of this study was to investigate the effects of an 8-week aquatic aerobic training program on serum levels of interleukin-4 (IL-4) and malondialdehyde (MDA) in breast cancer survivors.
Methods: This quasi-experimental study involved 20 breast cancer survivors who were randomly assigned to either an experimental group (n = 10) that underwent aquatic aerobic exercise or a control group (n = 10) that received no intervention. Pre- and post-test measurements of IL-4 and MDA levels were taken to assess the impact of the exercise intervention. The aquatic aerobic training program lasted 8 weeks, with sessions held three times per week. Serum levels of IL-4 and MDA were measured using enzyme-linked immunosorbent assays (ELISA).
Results: The results revealed a significant reduction in IL-4 levels in the experimental group (p = 0.001), while no significant change was observed in the control group (p = 0.861). Similarly, MDA levels were significantly reduced in the experimental group (p = 0.001), while the control group showed no significant change (p = 0.659). These findings suggest that aquatic aerobic exercise may reduce inflammation and oxidative stress in breast cancer survivors.
Conclusion: In conclusion, aquatic aerobic exercise appears to be a beneficial intervention for improving inflammatory and oxidative biomarkers in breast cancer survivors, potentially contributing to better long-term health outcomes.
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