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Synergistic Effects of Curcumin Supplementation and High-Intensity Interval Training on Mitochondrial Antioxidant Enzymes in the Hippocampus of Aged Rats | ||
| New Approaches in Exercise Physiology | ||
| دوره 6، شماره 12، اسفند 2024، صفحه 312-340 اصل مقاله (378.88 K) | ||
| نوع مقاله: Research Paper | ||
| شناسه دیجیتال (DOI): 10.22054/nass.2025.90197.1222 | ||
| نویسندگان | ||
| Reza Farzizadeh* 1؛ Nastaran Zarezadeh2؛ Bahareh Varcheney3 | ||
| 1Department of Physical Education and Sport Sciences, Faculty of Education Sciences and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran. | ||
| 2Department of Exercise Physiology, Islamic Azad University, Borujerd Branch, Borujerd, Iran. | ||
| 3Department of Sports Sciences, Faculty of human Sciences, Malayer University, Malayer, Iran. | ||
| چکیده | ||
| Purpose: Aging is accompanied by progressive mitochondrial dysfunction and increased oxidative stress, particularly within the hippocampus, a brain region highly vulnerable to metabolic impairment and redox imbalance. Curcumin, a polyphenolic compound with potent antioxidant and anti-inflammatory properties, and high-intensity interval training (HIIT), a time-efficient exercise modality known to stimulate mitochondrial biogenesis, may offer complementary neuroprotective benefits. This study examined the synergistic effects of curcumin supplementation and HIIT on mitochondrial antioxidant enzymes in the hippocampus of aged rats. Method: Thirty-two male Wistar rats (22–24 months) were randomly assigned to four groups: Control, Curcumin (100 mg/kg/day), HIIT, and Curcumin + HIIT. The 8-week HIIT protocol consisted of treadmill-based intervals performed five days per week, while hippocampal mitochondrial fractions were analyzed for superoxide dismutase 2 (SOD2), catalase (CAT), and glutathione peroxidase (GPx). Oxidative stress markers, including reactive oxygen species (ROS), malondialdehyde (MDA), and reduced glutathione (GSH), were also quantified. Results: Both curcumin and HIIT independently increased SOD2, CAT, and GPx activities (p < 0.01), but the combined intervention produced significantly greater enhancements across all enzyme systems (p < 0.001). ROS and MDA levels were markedly reduced in the Curcumin + HIIT group compared with all other groups (p < 0.001), while GSH content increased by more than 100% relative to controls. Effect sizes were large for all mitochondrial and oxidative stress outcomes, indicating robust physiological adaptation. Conclusion: These findings demonstrate that curcumin supplementation synergistically enhances the mitochondrial antioxidant and redox benefits of HIIT in the aging hippocampus. Integrating targeted nutraceuticals with structured high-intensity exercise may represent a promising strategy for mitigating age-related oxidative dysfunction and supporting long-term brain health. | ||
| کلیدواژهها | ||
| Curcumin؛ High-intensity interval training؛ Mitochondrial antioxidants؛ Hippocampus؛ Aging؛ Oxidative | ||
| مراجع | ||
|
Agarwal, N. B., Kulkarni, S., & Sharma, G. (2020). Curcumin and exercise: A review of their effect on oxidative stress and aging. Biomedicine & Pharmacotherapy, 127, 110116.
Alghamdi, B. S. (2023). Exercise-induced changes in mitochondrial dynamics in the aging brain. Neurobiology of Aging, 122, 45–56.
Arnoczky, S. P., Lavagnino, M., & Egerbacher, M. (2021). Aging and oxidative stress in neuronal tissue. Experimental Gerontology, 151, 111404.
Asadi, A., Arazi, H., Suzuki, K., & Lastayo, P. C. (2022). Highintensity interval training improves biomarkers of oxidative stress. Journal of Strength and Conditioning Research, 36(1), 15– 24.
Bansal, S., & Chaturvedi, D. (2019). Curcumin's neuroprotective potential in neurodegenerative diseases. Phytotherapy Research, 33(7), 1951–1964.
Bekinschtein, P., Cammarota, M., & Medina, J. H. (2020). Role of the hippocampus in memory and oxidative stress. Frontiers in Neuroscience, 14, 567.
Bergen, H. R., & Little, J. P. (2018). HIIT-induced neuroplasticity. Exercise and Sport Sciences Reviews, 46(3), 137–145.
Bhat, A. H., Dar, K. B., & Anees, S. (2015). Oxidative stress and mitochondrial dysfunction in aging. Cellular and Molecular Life Sciences, 72, 4711–4729.
Butterfield, D. A., & Halliwell, B. (2019). Oxidative stress, mitochondria, and aging brain. Nature Reviews Neuroscience, 20(3), 148–160.
Calabrese, V., Santoro, A., & Monti, D. (2020). Redox homeostasis in brain aging. Antioxidants & Redox Signaling, 34(10), 745–785.
Caruso, G., Fresta, C., & Martinez-Besteiro, E. (2021). Oxidative stress and age-related neurodegeneration. Antioxidants, 10(12), 1895.
Chakrabarti, S., D'Souza, R., & Kabaso, D. (2020). Mitochondrial dysfunction in aging brain. Aging Research Reviews, 57, 100981.
Chaudhuri, A., & Behan, P. (2022). Exercise and mitochondrial quality control. Frontiers in Aging Neuroscience, 14, 832102.
Chen, Z., Zhong, C., & Chen, Y. (2021). Curcumin activates Nrf2 pathway in neural tissue. Journal of Nutritional Biochemistry, 98, 108812.
Cunha, C., Brambilla, R., & Thomas, K. (2010). The role of GSH in brain antioxidant defense. Neurochemistry International, 57(1), 45–52.
Davis, G. C., & Wright, C. (2021). Polyphenols and neuroprotection. Nutritional Neuroscience, 24(12), 957–969.
Dumke, C. L., Townsend, J. R., & Mutchler, J. (2022). HIIT and mitochondrial protein expression. Physiological Reports, 10(5), e15123.
Fasihi, L., Agha-Alinejad, H., Gharakhanlou, R., & J Amaro Gahete, F. (2025). Comparison and Prediction of Breast Cancer Using Discriminant Analysis Algorithm in Active and Inactive Women.
Physical Treatments-Specific Physical Therapy Journal, 15(3), 00.
Fisher, J. P., Young, C. N., & Fadel, P. J. (2023). Exercise and brain oxidative stress. Journal of Physiology, 601(2), 237–255.
Forrester, S. J., Kikuchi, D. S., Hernandes, M. S., & Xu, Q. (2018).
Mitochondrial oxidative stress and disease. Redox Biology, 15, 347–362.
Francois, M. E., & Little, J. P. (2017). HIIT and mitochondrial health. Applied Physiology, Nutrition, and Metabolism, 42(10), 1033– 1041.
Ghosh, S., Dey, K. K., & Chattopadhyay, D. (2019). Curcumin combats aging-induced neurodegeneration. Neurobiology of Aging, 80, 42–54.
Gibala, M. J., Gillen, J. B., & Percival, M. E. (2012). Physiological adaptations to HIIT. Sports Medicine, 42(5), 439–449.
Gomes, M. J., Pagan, L. U., & Okoshi, K. (2020). Exercise and oxidative stress. Life Sciences, 256, 117891.
Gomez-Cabrera, M. C., Domenech, E., & Ji, L. L. (2023). Antioxidant supplements and exercise adaptation. Free Radical Biology & Medicine, 198, 124–133.
Goranova, M. G., Rogozin, E. A., & Matta, C. (2022). The dual role of curcumin in redox modulation. Biochimie, 195, 58–71.
Grewal, A. K., Singh, T. G., & Sharma, D. (2020). Curcumin and neuroplasticity. Journal of Chemical Neuroanatomy, 106, 101765.
Hewlings, S. J., & Kalman, D. S. (2017). Curcumin: Health benefits and mechanisms. Foods, 6(10), 92.
Karuppagounder, S. S., Yang, A. J., & Kumar, A. (2022). Curcuminmediated mitochondrial regulation. Biomedicine & Pharmacotherapy, 147, 112664.
Karchegani, A. M., Tavakoli, M., Pourtahari, M., & Navarro
Valverde, F. A. (2025). Analyzing the Effectiveness of DecisionMaking Styles in the Preparation and Implementation of Rural Hadi Projects in Iran. Rural Development Strategies, 12(1).
Kerr, C. L., Adamo, D. E., & Li, H. (2021). Aging, mitochondria, and neuronal energy metabolism. Gerontology, 67(3), 308–321.
López-Otín, C., Blasco, M. A., & Partridge, L. (2023). The hallmarks of aging. Cell, 186(1), 1–22.
Maillard, F., Rousset, S., & Pereira, B. (2018). HIIT improves antioxidant defense in aging models. Journal of Gerontology: Biological Sciences, 73(11), 1441–1447.
Mattson, M. P., & Arumugam, T. V. (2018). Brain aging mechanisms. Nature Reviews Neuroscience, 19(10), 573–583.
Mhillaj, E., Cuomo, C., & Trabace, L. (2019). Curcumin and neuroinflammation. Pharmaceutics, 11(7), 325.
Paula, P. C., Silva, L. B., & Moreira, E. L. (2020). Exercise and hippocampal plasticity. Brain Research Bulletin, 157, 122–131.
Powers, S. K., Talbert, E. E., & Adhihetty, P. J. (2020). Oxidative stress and mitochondrial dysfunction. Physiological Reviews, 100(4), 1523–1617.
Qin, L., Vázquez-Sánchez, S., & Castellano, A. (2022). Mitochondrial redox regulation in neuronal aging. Antioxidants, 11(8), 1502.
Reljic, D., Frenk, Y., & Herrmann, H. J. (2025). HIIT and antioxidant gene expression. Physiological Reports, 13(1), e15876.
Sahoo, D. K., Roy, A., & Chainy, G. B. (2016). Age-related changes in GSH metabolism. Biogerontology, 17(1), 185–198.
Small, G. W., Siddarth, P., & Li, Z. (2021). Curcumin and brain health. American Journal of Geriatric Psychiatry, 29(4), 1–12.
Sultana, R., & Butterfield, D. A. (2018). Lipid peroxidation in neurodegeneration. Oxidative Medicine and Cellular Longevity, 2018, 3271670.
Sun, N., Youle, R. J., & Finkel, T. (2020). Mitophagy in aging and disease. Nature Reviews Molecular Cell Biology, 21(7), 381–397.
Tian, L., Cai, Q., & Wei, H. (2023). HIIT and SIRT3 activation in neurons. Brain Research, 1813, 147028.
Wang, X., Wang, Y., & Xia, Z. (2023). Curcumin and mitochondrial GSH regulation. Neuroscience Letters, 792, 136965.
Wei, L., Hou, X., & Liu, J. (2021). Exercise-induced mitochondrial biogenesis. Molecular Neurobiology, 58(3), 1234–1247.
Wu, J., Zhang, Y., & Li, B. (2022). Antioxidant responses of aged hippocampal neurons. Journal of Molecular Neuroscience, 72(1), 66–79.
Xie, L., Kang, K., & Xu, P. (2021). Anti-inflammatory effects of curcumin in the hippocampus. Journal of Neuroimmunology, 355, 577601.
Yin, F., Sancheti, H., & Cadenas, E. (2016). Mitochondrial redox imbalance in aging. Aging Cell, 15(2), 332–339.
Zhang, J., Wang, Z., & Zhang, Y. (2020). HIIT and hippocampal antioxidant responses. Neuroscience, 431, 160–172.
Zhao, Y., Wang, X., & Chen, M. (2022). Polyphenols and mitochondrial protection. Free Radical Research, 56(2), 155– 169. | ||
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