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Farzizadeh, Reza, Zarezadeh, Nastaran, Varcheney, Bahareh. (1403). Synergistic Effects of Curcumin Supplementation and High-Intensity Interval Training on Mitochondrial Antioxidant Enzymes in the Hippocampus of Aged Rats. سامانه مدیریت نشریات علمی, 6(12), -. doi: 10.22054/nass.2025.90197.1222
Reza Farzizadeh; Nastaran Zarezadeh; Bahareh Varcheney. "Synergistic Effects of Curcumin Supplementation and High-Intensity Interval Training on Mitochondrial Antioxidant Enzymes in the Hippocampus of Aged Rats". سامانه مدیریت نشریات علمی, 6, 12, 1403, -. doi: 10.22054/nass.2025.90197.1222
Farzizadeh, Reza, Zarezadeh, Nastaran, Varcheney, Bahareh. (1403). 'Synergistic Effects of Curcumin Supplementation and High-Intensity Interval Training on Mitochondrial Antioxidant Enzymes in the Hippocampus of Aged Rats', سامانه مدیریت نشریات علمی, 6(12), pp. -. doi: 10.22054/nass.2025.90197.1222
Farzizadeh, Reza, Zarezadeh, Nastaran, Varcheney, Bahareh. Synergistic Effects of Curcumin Supplementation and High-Intensity Interval Training on Mitochondrial Antioxidant Enzymes in the Hippocampus of Aged Rats. سامانه مدیریت نشریات علمی, 1403; 6(12): -. doi: 10.22054/nass.2025.90197.1222

Synergistic Effects of Curcumin Supplementation and High-Intensity Interval Training on Mitochondrial Antioxidant Enzymes in the Hippocampus of Aged Rats

New Approaches in Exercise Physiology
دوره 6، شماره 12، اسفند 2024
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22054/nass.2025.90197.1222
نویسندگان
Reza Farzizadeh* 1؛ Nastaran Zarezadeh2؛ Bahareh Varcheney3
1Associate Professor h, University of Mohaghegh Ardabili
2broujerd
3Malayer
چکیده
This study examined the synergistic effects of curcumin supplementation and HIIT on mitochondrial antioxidant enzymes in the hippocampus of aged rats.
Thirty-two male Wistar rats (22–24 months) were randomly assigned to four groups: Control, Curcumin (100 mg/kg/day), HIIT, and Curcumin + HIIT. The 8-week HIIT protocol consisted of treadmill-based intervals performed five days per week, while hippocampal mitochondrial fractions were analyzed for superoxide dismutase 2 (SOD2), catalase (CAT), and glutathione peroxidase (GPx). Oxidative stress markers, including reactive oxygen species (ROS), malondialdehyde (MDA), and reduced glutathione (GSH), were also quantified.
Both curcumin and HIIT independently increased SOD2, CAT, and GPx activities (p < 0.01), but the combined intervention produced significantly greater enhancements across all enzyme systems (p < 0.001). ROS and MDA levels were markedly reduced in the Curcumin + HIIT group compared with all other groups (p < 0.001), while GSH content increased by more than 100% relative to controls. Effect sizes were large for all mitochondrial and oxidative stress outcomes, indicating robust physiological adaptation.
These findings demonstrate that curcumin supplementation synergistically enhances the mitochondrial antioxidant and redox benefits of HIIT in the aging hippocampus. Integrating targeted nutraceuticals with structured high-intensity exercise may represent a promising strategy for mitigating age-related oxidative dysfunction and supporting long-term brain health.
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تعداد مشاهده مقاله: 2


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