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Azadpour, Noushin, Tartibian, Bakhtyar, Eslami, Rasoul, Fasihi, Leila, Beigi, Armita. (1405). Creatine Supplementation during Suspension Training Reduces Circulating Myostatin Without Additional Improvements in Physical Function in Inactive Older Men: A Randomized Placebo-Controlled Trial. سامانه مدیریت نشریات علمی, 8(16), -. doi: 10.22054/nass.2026.93780.1242
Noushin Azadpour; Bakhtyar Tartibian; Rasoul Eslami; Leila Fasihi; Armita Beigi. "Creatine Supplementation during Suspension Training Reduces Circulating Myostatin Without Additional Improvements in Physical Function in Inactive Older Men: A Randomized Placebo-Controlled Trial". سامانه مدیریت نشریات علمی, 8, 16, 1405, -. doi: 10.22054/nass.2026.93780.1242
Azadpour, Noushin, Tartibian, Bakhtyar, Eslami, Rasoul, Fasihi, Leila, Beigi, Armita. (1405). 'Creatine Supplementation during Suspension Training Reduces Circulating Myostatin Without Additional Improvements in Physical Function in Inactive Older Men: A Randomized Placebo-Controlled Trial', سامانه مدیریت نشریات علمی, 8(16), pp. -. doi: 10.22054/nass.2026.93780.1242
Azadpour, Noushin, Tartibian, Bakhtyar, Eslami, Rasoul, Fasihi, Leila, Beigi, Armita. Creatine Supplementation during Suspension Training Reduces Circulating Myostatin Without Additional Improvements in Physical Function in Inactive Older Men: A Randomized Placebo-Controlled Trial. سامانه مدیریت نشریات علمی, 1405; 8(16): -. doi: 10.22054/nass.2026.93780.1242

Creatine Supplementation during Suspension Training Reduces Circulating Myostatin Without Additional Improvements in Physical Function in Inactive Older Men: A Randomized Placebo-Controlled Trial

New Approaches in Exercise Physiology
دوره 8، شماره 16، اسفند 2026
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22054/nass.2026.93780.1242
نویسندگان
Noushin Azadpour* 1؛ Bakhtyar Tartibian2؛ Rasoul Eslami2؛ Leila Fasihi2؛ Armita Beigi2
1Department of Physiotherapy, Ardabil University of Medical Sciences, Ardabil, Iran
2Department of Exercise Physiology, Faculty of Physical Education and Sports Sciences, Allameh Tabataba’i University, Tehran, Iran
چکیده
Methods: In this randomized, double-blind, placebo-controlled trial, 22 inactive older men aged 65–85 years were assigned to suspension training plus creatine (TRX+Cr; n = 11) or suspension training plus placebo (TRX+Pla; n = 11). Both groups completed a supervised 6-week suspension training program. The TRX+Cr group received creatine monohydrate at 0.3 g·kg⁻¹·day⁻¹ throughout the intervention, whereas the TRX+Pla group received placebo. Outcomes included appendicular skeletal muscle mass index (ASMI), serum myostatin, follistatin, insulin-like growth factor-1 (IGF-1), vitamin D, handgrip strength, five-times sit-to-stand (5xSTS), and Short Physical Performance Battery (SPPB). Between-group differences were analyzed using ANCOVA adjusted for baseline values.

Results: Creatine supplementation produced a greater reduction in circulating myostatin compared with placebo (p < 0.001). A significant between-group difference was also observed for follistatin (p = 0.002); however, this reflected a decrease in the creatine group and should not be interpreted as a favorable anabolic response. ASMI did not differ significantly between groups (p = 0.051). No significant between-group differences were observed for IGF-1, vitamin D, handgrip strength, 5xSTS, or SPPB.

Conclusion: Creatine supplementation during 6 weeks of suspension training reduced circulating myostatin in inactive older men, but this biomarker response was not accompanied by statistically significant additional improvements in ASMI, physical function, IGF-1, or vitamin D.
کلیدواژه‌ها
Creatine supplementation؛ suspension training؛ inactive older men؛ myostatin؛ muscle-related biomarkers؛ physical function
آمار
تعداد مشاهده مقاله: 1


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