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Kushkestani, Mehdi, Moghadassi, Mahsa, parvani, mohsen, baradaran, raheleh. (1401). Effect of resistance training on FTO and PPAR-y genes expression in muscle tissue of obese diabetic rats.. سامانه مدیریت نشریات علمی, 4(7), 214-235. doi: 10.22054/nass.2023.71785.1123
Mehdi Kushkestani; Mahsa Moghadassi; mohsen parvani; raheleh baradaran. "Effect of resistance training on FTO and PPAR-y genes expression in muscle tissue of obese diabetic rats.". سامانه مدیریت نشریات علمی, 4, 7, 1401, 214-235. doi: 10.22054/nass.2023.71785.1123
Kushkestani, Mehdi, Moghadassi, Mahsa, parvani, mohsen, baradaran, raheleh. (1401). 'Effect of resistance training on FTO and PPAR-y genes expression in muscle tissue of obese diabetic rats.', سامانه مدیریت نشریات علمی, 4(7), pp. 214-235. doi: 10.22054/nass.2023.71785.1123
Kushkestani, Mehdi, Moghadassi, Mahsa, parvani, mohsen, baradaran, raheleh. Effect of resistance training on FTO and PPAR-y genes expression in muscle tissue of obese diabetic rats.. سامانه مدیریت نشریات علمی, 1401; 4(7): 214-235. doi: 10.22054/nass.2023.71785.1123

Effect of resistance training on FTO and PPAR-y genes expression in muscle tissue of obese diabetic rats.

New Approaches in Exercise Physiology
دوره 4، شماره 7، شهریور 2022، صفحه 214-235    اصل مقاله (627.2 K)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22054/nass.2023.71785.1123
نویسندگان
Mehdi Kushkestani1؛ Mahsa Moghadassi2؛ mohsen parvani3؛ raheleh baradaran* 4
1Wellness and lifestyle science initiative group, Ph.D. student of kinesiology and health, school of art and science, Rutgers University New Brunswick, New Brunswick, New Jersey, United States
2M.Sc Student of Exercise Physiology, Department of Exercise Physiology, Islamic Azad University, Tehran North Branch, Tehran, Iran
3Ph.D. student of Sports Sciences, Faculty of Sports Sciences, University of Coimbra, Portugal
4Allameh Bohlool Gonabadi Hospital, Gonabad University of Medical Sciences, Gonabad, Iran
چکیده
Purpose: It has been well proven that type 2 diabetes is one of the most common non-communicable diseases leading to many complications and mortality every year. The aim of this study was to investigate the effect of resistance training on FTO and PPAR-y gene expression in muscle tissue of obese diabetic rats. Study design: This experimental study was performed on 12 male Wistar rats (10 weeks old and 220±20 g bodyweight). Methods: Animals received 6 weeks high-fat diet and then in order to induce type 2 diabetes an intraperitoneal injection of a single dose of 30 mg/kg freshly prepared streptozotocin (STZ) (Sigma, USA) solved in citrate buffer (pH 4.5) was performed. Diabetic rats were divided into two (Resistance and control) groups randomly. The resistance program included 6 weeks, 5 sessions per week. The muscle expression of FTO and PPAR-γ was measured using the real-time PCR method. Independent t-test and Analysis of covariance (ANCOVA) were applied to compare the means. Results: The muscle mRNA expression of PPAR-γ and body weight significantly increased after 6 weeks of resistance training (p=0.031, p=0.037; respectively) but there was no significant change in the muscle mRNA expression of FTO (p=0.317). Also, blood glucose significantly decreased in the training group compared to the control group (p=0.01). Conclusion: According to the results of this study, it can be noted that 6-week resistance training by decreasing glucose levels and increases insulin sensitivity, and the muscle expression of PPAR-γ plays a prominent role in the control and treatment of type 2 diabetes in obese patients.‎
کلیدواژه‌ها
Exercise؛ Metabolic diseases؛ Gene expression؛ Diabetics؛ Resistance training
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