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Effect of regular aerobic exercise on anti-inflammatory cytokines and chronic inflammation in elderly obese men | ||
| New Approaches in Exercise Physiology | ||
| مقاله 12، دوره 8، شماره 15، شهریور 2026 | ||
| نوع مقاله: Research Paper | ||
| شناسه دیجیتال (DOI): 10.22054/nass.2025.90645.1231 | ||
| نویسندگان | ||
| hamid agha alinejad1؛ Reza Gharakhanlou1؛ Leila Fasihi* 2 | ||
| 1Department of Physical Education and Sport Sciences, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran. | ||
| 2MSc Student of Exercise Physiology Department of Physical Education and sport science, Faculty of Physical Education and sport science, University of Allameh Tabatabai, Tehran, Iran | ||
| چکیده | ||
| Objective: Chronic low-grade inflammation is a common feature of aging, particularly in obese elderly individuals, and is associated with numerous chronic diseases such as cardiovascular disease, type 2 diabetes, and metabolic syndrome. Anti-inflammatory cytokines, such as IL 10 and IL 1ra, play a crucial role in modulating immune responses and mitigating inflammation. The aim of this study was to investigate Effect of regular aerobic exercise on anti-inflammatory cytokines and chronic inflammation in elderly obese men. Methods: This study utilized a quasi-experimental design with 24 obese elderly men (aged 60-75 years). Participants were randomly assigned to either the experimental group (n=12), who engaged in aerobic exercise (60 minutes, 3 times a week for 8 weeks), or the control group (n=12), who maintained their usual lifestyle without any structured exercise. Pre- and post-intervention blood samples were analyzed to measure IL 10 and IL 1ra levels. Descriptive and inferential statistics, including paired t-tests and independent t-tests, were used to assess changes in cytokine levels. Results: Significant increases were found in IL 10 (p=0.01) and IL 1ra (p=0.02) in the experimental group after the 8-week intervention. No significant changes were observed in the control group. Conclusion: This study demonstrates that regular aerobic exercise significantly improves immune function by increasing anti-inflammatory cytokines such as IL 10 and IL 1ra. This intervention may offer a valuable approach for managing inflammation-related diseases in obese elderly populations. | ||
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